Local synthesis of CaMKII: Where, how and why?
June 13, 2023 I 4 pm | BCCN Lecture Hall Philippstraße 13 Haus 6, 10115 Berlin + ZOOM Meeting-ID: 775 491 0236Brain function relies on the ability of neurons to build and modulate specialized structures for sending and receiving information at sites far from the soma. The molecular mechanismsnunderlying this cell biological feat are incompletely understood, but one important component is the ability of neurons to translate specific mRNAs at synaptic sites. Locally synthesized protein is critical for plasticity in the mature nervous system and is a well-established requirement for long-term memory. Across phyla, activity patterns that drive long-term plasticity cause increased synthesis and synaptic accumulation of CaMKII.
In this talk, I will tell you about work in my lab defining both cis and trans elements that are required for establishing the enrichment of CaMKII in the presynaptic terminals of Drosophila mushroom body Kenyon cells and discuss the role of neuronal activity in increasing local CaMKII levels both pre- and postsynaptically at the larval neuromuscular junction.
About the Speaker: Leslie Claire Griffith is a Nancy Lurie Marks Professor of Neuroscience and Director of the Volen National Center for Complex Systems at the Brandeis University (Waltham MA).
Certificate of attendance: Please contact team assistant serenella.brinati.1@hu-berlin.de
This talk is hosted by AG Owald (A07). David Owald will introduce and SFB1315 Speaker
Matthew Larkum will moderate the Q&A.
