Project
Die Suche nach Engrammen in einem µStim-basierten Gedächtniskonsolidierungs-Paradigma
In diesem Projekt werden wir anhand einer bereits erfolgreich von uns eingesetzten Mikrostimulations-basierten Lernaufgabe (µStim) die System-Gedächtniskonsolidierung untersuchen. Wir konnten zeigen, dass die Bildung von Gedächtnis-Engrammen im Neokortex abhängig von Input aus dem medialen Temporallappen ist. Darauf basierend stellen wir die Hypothese auf, dass µStim-Lernen mit einem Gating von Top-Down-Inputs zur Schicht 1 des Kortex einhergeht. In den hier beantragten Experimenten werden wir die Evolution von kortikalen Engrammen in der gesamten kortikalen Säule während µStim mit Hilfe von Neuropixels-Elektrodenarrays, 2-Photonen-Bildgebung und chronisch implantierten Prismen verfolgen.
Bild Kortikale Pyramidenneuronen. Quelle, Matthew Larkum und Mostafa Abdelhamid
Team
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Prof Matthew Larkum PhD
Humboldt-Universität zu Berlin
Spokesperson, Head Larkum Lab
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Dr Mostafa Nashaat
Humboldt-Universität zu Berlin
A04 Postdoc
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Anna Nasr
Humboldt-Universität zu Berlin
INF PhD (A04 Associated PhD)
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Serenella Brinati
Humboldt-Universität zu Berlin
Team Assistant & Secretary AG Larkum
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Dr Jiyun Shin
New York University
A04 Alumna
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Dr Guy Doron
Bayer Pharmaceuticals Berlin
A04 Alumnus
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Dr Naoya Takahashi
Université de Bordeaux
Head Takahashi Lab - A04 Alumnus
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Lisa De Mont
Charité-Universitätsmedizin Berlin
Student Helper 2018-2019 - A04 Alumna
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Sara Moberg
Charité – Universitätsmedizin Berlin
A04 Alumna
Publications
The neural mechanisms of fast versus slow decision-making
Mostafa Nashaat, Hatem Oraby, Flutra Krasniqi, Sek Teng Goh-Sauerbier, Marion Bosc, Sandra Koerner, Sedef Karayel, Adam Kepecs, Matthew E. Larkum
bioRxiv (2024)
Neocortical layer 5 subclasses: From cellular properties to roles in behavior
Sara Moberg and Naoya Takahashi
Front Synaptic Neurosci. 14:1006773 (2022)
The guide to dendritic spikes of the mammalian cortex in vitro and in vivo
Matthew E. Larkum, Jiameng Wu, Sarah A. Duverdin and Albert Gidon
Neuroscience 489:15–3 (2022)
Post-encoding modulation of spatial memory consolidation by propofol
Deetje Iggena, Patrizia M. Maier, Sophia M. Häußler, Mario Menk, Heidi Olze, Matthew E. Larkum, Carsten Finke, Christoph J. Ploner
Cortex 156, 1-12 (2022)
Are Dendrites Conceptually Useful?
Matthew E. Larkum
Neuroscience. 1;489:4-14 (2022)
Deep tissue scattering compensation with three-photon F-SHARP
Caroline Berlage, Malinda Tantirigama, Mathias Babot, Diego Di Battista, Clarissa Whitmire, Ioannis N. Papadopoulos, James F. A. Poulet, Matthew Larkum, Benjamin Judkewitz
Optica. 8:1613-1619 (2021)
Double-μ Periscope: a tool for multi-layer optical recordings, optogenetic stimulations or both
Mototaka Suzuki, Jaan Aru and Matthew E. Larkum
eLife 2021;10:e72894 (2021)
Memories off the top of your head
Jiyun N. Shin, Guy Doron, Matthew E. Larkum
Science. 374(6567): 538-539 (2021)
Thalamic input to motor cortex facilitates goal-directed action initiation
Naoya Takahashi, Sara Moberg, Timothy A. Zolnik, Julien Catanese, Robert N.S. Sachdev, Matthew E. Larkum, Dieter Jaeger
Curr Biol. 31(18):4148-4155.e4 (2021)
Layer 6b is driven by intracortical long-range projection neurons
Timothy A. Zolnik, Julia Ledderose, Maria Toumazou, Thorsten Trimbuch, Tess Oram, Christian Rosenmund, Britta J. Eickholt, Robert N.S. Sachdev, Matthew E. Larkum
Cell Rep. 30(10):3492-3505.e5 (2020)
Perirhinal input to neocortical layer 1 controls learning
Guy Doron, Jiyun N Shin, Naoya Takahashi, Moritz Drüke, Christina Bocklisch, Salina Skenderi, Lisa de Mont, Maria Toumazou, Julia Ledderose, Michael Brecht, Richard Naud and Matthew E Larkum
Science. 370(6523):eaaz3136
Up and down states across somatosensory, entorhinal, and hippocampal cortices
John J Tukker, Prateep Beed, Dietmar Schmitz, Matthew E Larkum and Robert NS Sachdev
Front Syst Neurosci. 14:22 (2020)
Perspective on the multiple pathways to changing brain states
Malinda LS Tantirigama, Timothy Zolnik, Benjamin Judkewitz, Matthew E Larkum and Robert NS Sachdev
Front Syst Neurosci. 14:23 (2020)
Active dendritic currents gate descending cortical outputs in perception
Naoya Takahashi, Christian Ebner, Johanna Sigl-Glöckner, Sara Moberg, Svenja Nierwetberg and Matthew E Larkum
Nat Neurosci. 23(10):1277-1285 (2020)
General anesthesia decouples cortical pyramidal neurons
Mototaka Suzuki and Matthew E Larkum
Cell. 180(4):666-676.e13 (2020)
Dynamic conjugate F-SHARP microscopy
Ioannis N Papadopoulos, Jean-Sebastien Jouhanneau, Naoya Takahashi, David Kaplan, Matthew Larkum, James Poulet and Benjamin Judkewitz
Light Sci Appl. 9:110 (2020)
Effects of sexual experience and puberty on mouse genital cortex revealed by chronic imaging
Johanna Sigl-Glöckner, Eduard Maier, Naoya Takahashi, Robert Sachdev, Matthew Larkum, Michael Brecht
Curr Biol. 29(21):3588-3599.e4 (2019)
Whisking asymmetry signals motor preparation and the behavioral state of mice
Sina E Dominiak, Mostafa A Nashaat, Keisuke Sehara, Hatem Oraby, Matthew E Larkum, and Robert NS Sachdev
J Neurosci. 39(49):9818-9830 (2019)
Cellular mechanisms of conscious processing
Jaan Aru, Mototaka Suzuki and Matthew E Larkum
Trends Cogn Sci. 24: 814-825 (2020)
Fast, flexible closed-Loop feedback: tracking movement in “real-millisecond-time”
Keisuke Sehara, Viktor Bahr, Ben Mitchinson, Martin J Pearson, Matthew E Larkum and Robert NS Sachdev
eNeuro. 6(6):ENEURO.0147-19.2019
