Projects
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A01
Role of heterogeneous pyramidal cell populations and specific connectivity motifs in pattern completion and replay of memory sequences
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A02
Differential embedding of hippocampal output neurons during memory-related oscillations
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C01
Development of molecular tools for manipulating and studying memory engrams
Publications
Social play behavior is driven by glycine-dependent mechanisms
Anton Dvorzhak, Michael Brecht, Dietmar Schmitz
Curr Biol. 34(16):3654-3664.e6 (2024)
Propagation of sharp wave-ripple activity in the mouse hippocampal CA3 subfield in vitro
Natalie Schieferstein, Ana del Toro, Roberta Evangelista, Barbara Imbrosci, Aarti Swaminathan, Dietmar Schmitz, Nikolaus Maier, Richard Kempter
J Physiol. 602(19):5039-5059 (2024)
Genetic identification of novel medullary neurons underlying congenital central hypoventilation syndrome
Ke Cui, Yiling Xia, Abhisarika Patnaik, Elijah D. Lowenstein, Eser Göksu Isik, Adrian L. Knorz, Laura Airaghi, Michela Crotti, Michèle Studer, Filippo M. Rijli, Hans G. Nothwang, Luis R. Hernandez-Miranda
Sci Adv. 10(25):eadj0720 (2024)
Simultaneous spectral illumination of microplates for high-throughput optogenetics and photobiology
Arend Vogt, Raik Paulat, Daniel Parthier, Verena Just, Michal Szczepek, Patrick Scheerer,
Qianzhao Xu, Andreas Möglich, Dietmar Schmitz, Benjamin R. Rost and Nikolaus WengerBiol Chem (2024)
Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking
Claire Cooper, Daniel Parthier, Jérémie Sibille, John Tukker, Nicolas X. Tritsch, Dietmar Schmitz
bioRxiv (2024)
Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves
Rosanna P. Sammons, Stefano Masserini, Laura Moreno-Velasquez, Verjinia D. Metodieva, Gaspar Cano, Andrea Sannio, Marta Orlando, Nikolaus Maier, Richard Kempter, Dietmar Schmitz
bioRxiv (2024)
Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
Janina Hesse, Jan-Hendrik Schleimer, Nikolaus Maier, Dietmar Schmitz, Susanne Schreiber
Nat Commun. 13(1):3934 (2022)
Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells
Alessia Urzi, Ines Lahmann, Lan Vi N. Nguyen, Benjamin R. Rost, Angélica García-Pérez, Noemie Lelievre, Megan E. Merritt-Garza, Han C. Phan, Gary J. Bassell, Wilfried Rossoll, Sebastian Diecke, Severine Kunz, Dietmar Schmitz & Mina Gouti
Nat Commun. 14(1):8043 (2023)
Structure and function of the hippocampal CA3 module
Rosanna P. Sammons, Mourat Vezir, Laura Moreno-Velasqueza, Gaspar Cano, Marta Orlando, Meike Sievers, Eleonora Grass, Verjinia D. Metodieva, Richard Kempter, Helene Schmidt and Dietmar Schmitz
PNAS. 121 (6) e2312281120 (2024)
Synthetic surprise as the foundation of the psychedelic experience
Roberto De Filippo, Dietmar Schmitz
Neurosci Biobehav Rev. 157:105538 (2024)
Hippocampal GABAergic interneurons and memory
Alexandra Tzilivaki, John J. Tukker, Nikolaus Maier, Panayiota Poirazi, Rosanna P. Sammons, Dietmar Schmitz
Neuron. 111 (2023)
Play and tickling responses map to the lateral columns of the rat periaqueductal gray
Natalie Gloveli, Jean Simonnet, Wei Tang, Miguel Concha-Miranda, Eduard Maier, Anton Dvorzhak, Dietmar Schmitz and Michael Brecht
Neuron. 111, 1–12 (2023)
A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits
Jonas Wietek, Adrianna Nozownik, Mauro Pulin, Inbar Saraf-Sinik, Noa Matosevich, Daniela Malan, Bobbie J. Brown, Julien Dine, Rivka Levy, Anna Litvin, Noa Regev, Suraj Subramaniam, Eyal Bitton, Asaf Benjamin, Bryan A. Copits, Philipp Sasse, Benjamin R. Rost, Dietmar Schmitz, Peter Soba, Yuval Nir, J. Simon Wiegert and Ofer Yizhar
Nat Methods (2024)
Gamma oscillation plasticity is mediated via parvalbumin interneurons
Michael D. Hadler, Alexandra Tzilivaki, Dietmar Schmitz, Henrik Alle, Jörg R. P. Geiger
Sci. Adv. 10,eadj7427(2024)
Differential ripple propagation along the hippocampal longitudinal axis
Roberto De Filippo, Dietmar Schmitz
eLife. 12:e85488 (2023)
Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling
Rodrigo G. Fernandez Lahore, Niccolò P. Pampaloni, Enrico Peter, M.-Marcel Heim, Linda Tillert, Johannes Vierock, Johannes Oppermann, Jakob Walther, Dietmar Schmitz, David Owald, Andrew J. R. Plested, Benjamin R. Rost, Peter Hegemann
Nat Commun. 13:7844 (2022)
Interneuron switching on and off across memory rhythms
Alexandra Tzilivaki, Nikolaus Maier, Dietmar Schmitz
Neuron. 110(12):1884-1886 (2022)
Optogenetics at the presynapse
Benjamin R. Rost, Jonas Wietek, Ofer Yizhar & Dietmar Schmitz
Nat Neurosci 25, 984–998 (2022)
GABAergic interneurons with nonlinear dendrites: from neuronal computations to memory engrams
Alexandra Tzilivaki, George Kastellakis, Dietmar Schmitz, Panayiota Poirazi
Neuroscience 489, 34-43 (2022)
Microcircuits for spatial coding in the medial entorhinal cortex
John J Tukker, Prateep Beed, Michael Brecht, Richard Kempter, Edvard I Moser, and Dietmar Schmitz
Physiol Rev. 102:653–688 (2022)
Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber boutons
Marta Orlando, Anton Dvorzhak, Felicitas Bruentgens, Marta Maglione, Benjamin R. Rost, Stephan J. Sigrist, Jörg Breustedt, Dietmar Schmitz
PLoS Biol. 19(6):e3001149 (2021)
Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin
M. Mahn, I. Saraf-Sinik, P. Patil, M. Pulin, E. Bitton, N. Karalis, F. Bruentgens, ..... D. Schmitz, A. Lüthi, B. R. Rost, J. S. Wiegert and O. Yizhar
Neuron. 109(10):1621-1635.e8 (2021)
Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex
Roberto de Filippo, Benjamin R Rost, Alexander Stumpf, Claire Cooper, John J Tukker, Christoph Harms, Prateep Beed, Dietmar Schmitz
eLife. 10:e66960 (2021)
A CRISPR-Cas9–engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions
Miguel Rodríguez de los Santos, Marion Rivalan, Friederike S. David, Alexander Stumpf, Julika Pitsch, Despina Tsortouktzidis, Laura Moreno Velasquez, Anne Voigt, Karl Schilling, Daniele Mattei, Melissa Long, Guido Vogt, Alexej Knaus, Björn Fischer-Zirnsak, Lars Wittler, Bernd Timmermann, Peter N. Robinson, Denise Horn, Stefan Mundlos, Uwe Kornak, Albert J. Becker, Dietmar Schmitz, York Winter and Peter M. Krawitz
Proc Natl Acad Sci USA. 118(2):e2014481118 (2021)
SynaptoPAC, an optogenetic tool for induction of presynaptic plasticity
Silvia Oldani, Laura Moreno‐Velasquez, Lukas Faiss, Alexander Stumpf, Christian Rosenmund, Dietmar Schmitz, Benjamin R Rost
J Neurochem. 156(3):324-336 (2021)
Layer 3 pyramidal cells in the medial entorhinal cortex orchestrate up-down states and entrain the deep layers differentially
Prateep Beed, Roberto de Filippo, Constance Holman, Friedrich W. Johenning, Christian Leibold, Antonio Caputi, Hannah Monyer, Dietmar Schmitz
Cell Reports. 33(10):108470 (2020)
Up and down states across somatosensory, entorhinal, and hippocampal cortices
John J Tukker, Prateep Beed, Dietmar Schmitz, Matthew E Larkum and Robert NS Sachdev
Front Syst Neurosci. 14:22 (2020)
Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway
Noam Nitzan, Sam McKenzie, Prateep Beed, Daniel Fine English, Silvia Oldani, John J Tukker, György Buzsáki and Dietmar Schmitz
Nat Commun. 11(1):1947 (2020)
Generation of sharp wave-ripple events by disinhibition
Roberta Evangelista, Gaspar Cano, Claire Cooper, Dietmar Schmitz, Nikolaus Maier and Richard Kempter
J Neurosci. 40(41):7811-7836 (2020)
Spikelets in pyramidal neurons: generating mechanisms, distinguishing properties, and functional implications
Martina Michalikova, Michiel WH Remme, Dietmar Schmitz, Susanne Schreiber and Richard Kempter
Rev Neurosci. 31(1):101-119 (2019)
