Jiyun N. Shin, Guy Doron, Matthew E. Larkum 

Memories are generally considered to be embodied in the connection strengths between neurons. Finding the exact synaptic connections responsible for memories out of hundreds of trillions at first appears impossible. But new research may be taking us a step closer. Specific brain areas under the neocortex are known to be required for memory formation (including the hippocampus and basal ganglia), while long-term memory relating to facts and knowledge (semantic memory) is thought to reside in the neocortex (1). However, the precise location of semantic memory is still unknown, preventing researchers from understanding how and where memories are formed.

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Science. 374(6567): 538-539 (2021)

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