Project
Zur Rolle von heterogenen Populationen von Pyramidenzellen und spezifischen Motiven der Konnektivität bei der Musterergänzung und dem Wiederabspielen von Gedächtnissequenzen
Sharp wave ripple-Komplexe (SWRs) sind kurze (50–100 ms) Episoden koordinierter neuronaler Aktivität, die im Hippocampus entstehen und die Konsolidierung expliziter Gedächtnisinhalte vermitteln. Die Mechanismen zur Steuerung des Auftretens von SWRs sind jedoch unbekannt. Um deren Dynamik besser zu verstehen, beabsichtigen wir die Rolle heterogener Populationen von Pyramidenzellen und spezifischen Motiven der Konnektivität bei der Musterergänzung und dem Wiederabspielen von Gedächtnissequenzen zu untersuchen, und zwar mit Hilfe von optogenetischen Methoden in vitro und in vivo und Netzwerkmodellen.
Image Poster-Ausschnitt, der das Modell der Interaktionen zwischen (P) Pyramidenzellen, PV+ (B) Basket-Zellen und (A) Anti-SWR-Zellen zeigt. Quelle, Richard Kempter und Gaspar Cano
Team
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Prof Dr Richard Kempter
Humboldt-Universität zu Berlin
Deputy Spokesperson, Head Theoretical Neuroscience Lab
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Prof Dr Dietmar Schmitz
Charité-Universitätsmedizin Berlin
Head Schmitz Lab
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Dr Nikolaus Maier
Charité–Universitätsmedizin Berlin
Senior Research Associate Neuroscience Research Center (NWFZ)
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Prof Dr med Seija Lehnardt
Charité – Universitätsmedizin Berlin
A01 A02 Associate PI
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Dr Laura Moreno Velasquez
Charité – Universitätsmedizin Berlin
A01 Postdoc (AG Schmitz)
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Dr med Jörg Breustedt
Charité – Universitätsmedizin Berlin
A01 Postdoc (AG Schmitz)
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Dr Marta Orlando
Charité-Universitätsmedizin Berlin
A01/A02 Associate Postdoc
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Dr Rosanna Sammons
Charité-Universitätsmedizin Berlin
A01 Associated Postdoc
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Alexandra Tzilivaki
Einstein Centre for Neurosciences Berlin
A01 Associate PhD
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Gaspar Cano
Humboldt-Universität zu Berlin
A01 PhD
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Stefano Masserini
A01 Associate PhD
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Claire Cooper
Charité-Universitätsmedizin Berlin
A01 PhD (C01 alumna)
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Dr Eric Reifenstein
Humboldt-Universität zu Berlin
B01 Alumnus
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Dr Natalie Schieferstein
University of Bonn
A01 Alumna
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Dr Roberta Evangelista
BASE Foundation, Basel Switzerland
A01 Alumna
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Tizia Kaplan
(A01 Alumna) Student helper 2019
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Ana Toro
Humboldt-Universität zu Berlin
Student helper 2020-2021 - A01 Alumna
Publications
Propagation of sharp wave-ripple activity in the mouse hippocampal CA3 subfield in vitro
Natalie Schieferstein, Ana del Toro, Roberta Evangelista, Barbara Imbrosci, Aarti Swaminathan, Dietmar Schmitz, Nikolaus Maier, Richard Kempter
J Physiol. 602(19):5039-5059 (2024)
Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking
Claire Cooper, Daniel Parthier, Jérémie Sibille, John Tukker, Nicolas X. Tritsch, Dietmar Schmitz
bioRxiv (2024)
Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves
Rosanna P. Sammons, Stefano Masserini, Laura Moreno-Velasquez, Verjinia D. Metodieva, Gaspar Cano, Andrea Sannio, Marta Orlando, Nikolaus Maier, Richard Kempter, Dietmar Schmitz
bioRxiv (2024)
Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
Janina Hesse, Jan-Hendrik Schleimer, Nikolaus Maier, Dietmar Schmitz, Susanne Schreiber
Nat Commun. 13(1):3934 (2022)
Intra-ripple frequency accommodation in an inhibitory network model for hippocampal ripple oscillations
Natalie Schieferstein , Tilo Schwalger, Benjamin Lindner, Richard Kempter
PLoS Comput Biol. 20(2): e1011886 (2024)
Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells
Alessia Urzi, Ines Lahmann, Lan Vi N. Nguyen, Benjamin R. Rost, Angélica García-Pérez, Noemie Lelievre, Megan E. Merritt-Garza, Han C. Phan, Gary J. Bassell, Wilfried Rossoll, Sebastian Diecke, Severine Kunz, Dietmar Schmitz & Mina Gouti
Nat Commun. 14(1):8043 (2023)
Structure and function of the hippocampal CA3 module
Rosanna P. Sammons, Mourat Vezir, Laura Moreno-Velasqueza, Gaspar Cano, Marta Orlando, Meike Sievers, Eleonora Grass, Verjinia D. Metodieva, Richard Kempter, Helene Schmidt and Dietmar Schmitz
PNAS. 121 (6) e2312281120 (2024)
Synthetic surprise as the foundation of the psychedelic experience
Roberto De Filippo, Dietmar Schmitz
Neurosci Biobehav Rev. 157:105538 (2024)
Hippocampal GABAergic interneurons and memory
Alexandra Tzilivaki, John J. Tukker, Nikolaus Maier, Panayiota Poirazi, Rosanna P. Sammons, Dietmar Schmitz
Neuron. 111 (2023)
Gamma oscillation plasticity is mediated via parvalbumin interneurons
Michael D. Hadler, Alexandra Tzilivaki, Dietmar Schmitz, Henrik Alle, Jörg R. P. Geiger
Sci. Adv. 10,eadj7427 (2024)
Differential ripple propagation along the hippocampal longitudinal axis
Roberto De Filippo, Dietmar Schmitz
eLife. 12:e85488 (2023)
Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling
Rodrigo G. Fernandez Lahore, Niccolò P. Pampaloni, Enrico Peter, M.-Marcel Heim, Linda Tillert, Johannes Vierock, Johannes Oppermann, Jakob Walther, Dietmar Schmitz, David Owald, Andrew J. R. Plested, Benjamin R. Rost, Peter Hegemann
Nat Commun. 13:7844 (2022)
Interneuron switching on and off across memory rhythms
Alexandra Tzilivaki, Nikolaus Maier, Dietmar Schmitz
Neuron. 110(12):1884-1886 (2022)
GABAergic interneurons with nonlinear dendrites: from neuronal computations to memory engrams
Alexandra Tzilivaki, George Kastellakis, Dietmar Schmitz, Panayiota Poirazi
Neuroscience 489, 34-43 (2022)
A neural code for egocentric spatial maps in the human medial temporal lobe
Lukas Kunz, Armin Brandt, Peter C. Reinacher, Bernhard P. Staresina, Eric T. Reifenstein, Christoph T. Weidemann, Nora A. Herweg, Ansh Patel, Melina Tsitsiklis, Richard Kempter, Michael J. Kahana, Andreas Schulze-Bonhage, Joshua Jacobs
Neuron. 109(17) 2781-2796.e10 (2021)
Microcircuits for spatial coding in the medial entorhinal cortex
John J Tukker, Prateep Beed, Michael Brecht, Richard Kempter, Edvard I Moser, and Dietmar Schmitz
Physiol Rev. 102:653–688 (2022)
Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber boutons
Marta Orlando, Anton Dvorzhak, Felicitas Bruentgens, Marta Maglione, Benjamin R. Rost, Stephan J. Sigrist, Jörg Breustedt, Dietmar Schmitz
PLoS Biol. 19(6):e3001149 (2021)
Synaptic learning rules for sequence learning
Eric T. Reifenstein, Ikhwan Bin Khalid, Richard Kempter
eLife. 10:e67171 (2021)
The sensory coding of warm perception
Ricardo Paricio-Montesinos, Frederick Schwaller, Annapoorani Udhayachandran, Florian Rau, Jan Walcher, Roberta Evangelista, Joris Vriens, Thomas Voets, James FA Poulet, Gary R Lewin
Neuron. 106(5):830-841.e3 (2020)
Generation of sharp wave-ripple events by disinhibition
Roberta Evangelista, Gaspar Cano, Claire Cooper, Dietmar Schmitz, Nikolaus Maier and Richard Kempter
J Neurosci. 40(41):7811-7836 (2020)
Spikelets in pyramidal neurons: generating mechanisms, distinguishing properties, and functional implications
Martina Michalikova, Michiel WH Remme, Dietmar Schmitz, Susanne Schreiber and Richard Kempter
Rev Neurosci. 31(1):101-119 (2019)
Extracellular waveforms reveal an axonal origin of spikelets in pyramidal neurons
Martina Michalikova, Michiel WH Remme and Richard Kempter
J Neurophysiol. 120(4):1484-1495 (2018)
Interneuronal gap junctions increase synchrony and robustness of hippocampal ripple oscillations
André Holzbecher, Richard Kempter
Eur J Neurosci. 48(12):3446-3465 (2018)
