Project
Veränderungen in layer-spezifischer kortikaler Konnektivität und subkortikaler Neuromodulation während der Gedächtniskonsolidierung
Unser Projekt untersucht wie sich das funktionelle Zusammenspiel von an der Gedächtnisbildung beteiligten Hirnstrukturen während der Konsolidierung verändert und zu welchem Zeitpunkt Hirnplastizität im Zusammenhang mit Gedächtnisengrammen beobachtbar ist. Hierzu verwenden wir einen neu- und einzigartigen 7T Connectome MR Scanner, um eine Abbildung funktioneller und struktureller Veränderungen mit bisher unerreichter Auflösung beim Menschen zu erreichen. Dies wird uns erlauben den Übergang von hippokampalzentrierter zu kortiko-kortikaler funktioneller Konnektivität während der Gedächtniskonsolidierung mit schichtspezifischer Auflösung im Kortex abzubilden. Durch die layer-spezifische Auflösung unserer Bildgebungsverfahren werden wir einen Brückenschlag zwischen Tier- und Menschenforschung in der Gedächtniskonsolidierung ermöglichen.
Image Single-subject mean PET-Bilder, die auf einem T1-Bild überlargerte sind. Quelle, (Alex) Yeo Jin Yi
Team
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Prof Dr Emrah Düzel
Otto von Guericke - Universität Magdeburg
Director, Institute of Cognitive Neurology and Dementia Research
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Dr Dorothea Hämmerer
Otto von Guericke - Universität Magdeburg
Head Hämmerer Lab
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Prof Dr Oliver Speck
Otto-von-Guericke University Magdeburg
Director Dept Biomedical Magnetic Resonance
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Alex (Yeo Jin) Yi
Otto von Guericke - Universität Magdeburg
B06 PhD
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Aditya Nemali
Otto von Guericke - Universität Magdeburg
B06 PhD
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Dr Matthew Betts
Otto-von-Guericke University Magdeburg
B06 Alumnus
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Sewda Yavari-Nodouzaghi
Otto-von-Guericke University Magdeburg
Student helper 2018-2019 - B06 Alumna
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Mareike Ludwig
Otto-von-Guericke University Magdeburg
Student helper 2018-2019 - B06 Alumna
Publications
Healthy aging and Alzheimer’s disease
Matthew J. Betts, Valentina Peros, Dorothea Hämmerer, Emrah Düzel
Adv Magn Reson Technol Appl. 10:2666-9099 (2023)
Cholinergic neuromodulation in the aging brain – Implications for neuropsychiatric diseases: Commentary on “neuromodulatory systems in aging and disease” special issue
Marina Leiman, Mareike Ludwig, Friedrich Krohn, Dorothea Hämmerer, Yeo-Jin Yi
Neurosci Biobehav Rev. 161:105654 (2024)
Cerebrospinal fluid and positron-emission tomography biomarkers for noradrenergic dysfunction in neurodegenerative diseases: a systematic review and meta-analysis
Elisa Lancini, Lena Haag, Franziska Bartl, Maren Rühling, Nicholas J Ashton, Henrik Zetterberg, Emrah Düzel, Dorothea Hämmerer, Matthew J Betts
Brain Commun. 5(3):fcad085 (2023)
Noradrenergic neuromodulation in ageing and disease
F. Krohn, E. Lancini, M. Ludwig, M. Leiman, G. Guruprasath, L. Haag, J. Panczyszyn, E. Düzel, D. Hämmerer, M. Betts
Neurosci Biobeh Rev. 152;105311 (2023)
The Past, Present, and Future of the Brain Imaging Data Structure (BIDS)
Russell A. Poldrack, Christopher J. Markiewicz, Stefan Appelhoff, Yoni K. Ashar, Tibor Auer, Sylvain Baillet, Shashank Bansal, Leandro Beltrachini, Christian G. Benar, Giacomo Bertazzoli, Suyash Bhogawar, Ross W. Blair, Marta Bortoletto, Mathieu Boudreau, Teon L. Brooks, Vince D. Calhoun, Filippo Maria Castelli, Patricia Clement Alexander L. Cohen, Julien Cohen-Adad, Sasha D’Ambrosio, Gilles de Hollander, María de la Iglesia-Vayá, Alejandro de la Vega, Arnaud Delorme, Orrin Devinsky, Dejan Draschkow, Eugene Paul Duff, Elizabeth DuPre, Eric Earl, Oscar Esteban, Franklin W. Feingold, Guillaume Flandin, Anthony Galassi, Giuseppe Gallitto, Melanie Ganz, Rémi Gau, James Gholam, Satrajit S. Ghosh, Alessio Giacomel, Ashley G. Gillman, Padraig Gleeson, Alexandre Gramfort, Samuel Guay, Giacomo Guidali, Yaroslav O. Halchenko, Daniel A. Handwerker, Nell Hardcastle, Peer Herholz, Dora Hermes, Christopher J. Honey, Robert B. Innis, Horea-Ioan Ioanas, Andrew Jahn, Agah Karakuzu, David B. Keator, Gregory Kiar, Balint Kincses, Angela R. Laird, Jonathan C. Lau, Alberto Lazari, Jon Haitz Legarreta, Adam Li, Xiangrui Li, Bradley C. Love, Hanzhang Lu, Eleonora Marcantoni, Camille Maumet, Giacomo Mazzamuto, Steven L. Meisler, Mark Mikkelsen, Henk Mutsaerts, Thomas E. Nichols, Aki Nikolaidis, Gustav Nilsonne, Guiomar Niso, Martin Norgaard, Thomas W. Okell, Robert Oostenveld, Eduard Ort, Patrick J. Park, Mateusz Pawlik, Cyril R. Pernet, Franco Pestilli, Jan Petr, Christophe Phillips, Jean-Baptiste Poline, Luca Pollonini, Pradeep Reddy Raamana, Petra Ritter, Gaia Rizzo, Kay A. Robbins, Alexander P. Rockhill, Christine Rogers, Ariel Rokem, Chris Rorden, Alexandre Routier, Jose Manuel Saborit-Torres, Taylor Salo, Michael Schirner, Robert E. Smith, Tamas Spisak, Julia Sprenger, Nicole C. Swann, Martin Szinte, Sylvain Takerkart, Bertrand Thirion, Adam G. Thomas, Sajjad Torabian, Gael Varoquaux, Bradley Voytek, Julius Welzel, Martin Wilson, Tal Yarkoni, and Krzysztof J. Gorgolewski
ArXiv [Preprint] arXiv:2309.05768v2 (2024)
Learning how network structure shapes decision-making for bio-inspired computing
Michael Schirner, Gustavo Deco, Petra Ritter
Nat Commun. 14, 2963 (2023)
Brain simulation augments machine-learning-based classification of dementia
Paul Triebkorn , Leon Stefanovski, Kiret Dhindsa, Margarita-Arimatea Diaz-Cortes, Patrik Bey, Konstantin Bülau, Roopai Pai, Anreas Spiegler, Ana Solodkin, Viktor Jirsa, Anthony R. McIntosh, Petra Ritter
Alzheimer’s Dement. 2022;8:e12303 (2022)
It is the Locus Coeruleus! Or… is it? : A proposition for analyses and reporting standards for structural and functional magnetic resonance imaging of the noradrenergic Locus Coeruleus
Yeo-Jin Yi, Falk Lüsebrink, Anne Maaß, Gabriel Ziegler, Renat Yakupov, Michael C. Kreißl, Matthew Betts, Oliver Speck, Emrah Düzel, Dorothea Hämmerer
Neurobiol Aging. 129:137-148 (2023)
Research data management in clinical neuroscience: the national research data infrastructure initiative
Carsten M. Klingner, Petra Ritter, Stefan Brodoehl, Christian Gaser, André Scherag, Daniel Güllmar, Felix Rosenow, Ulf Ziemann und Otto W. Witte
Neuroforum. 27(1):35-43 (2021)
NFDI-Neuro: Building a community for neuroscience research data management in Germany
Thomas Wachtler, Pavol Bauer, Michael Denker, Sonja Grün, Michael Hanke, Jan Klein, Steffen Oeltze-Jafra, Petra Ritter, Stefan Rotter, Hansjörg Scherberger, Alexandra Stein und Otto W. Witte
Neuroforum. 27(1):3-15 (2021)
Brain simulation as a cloud service: The Virtual Brain on EBRAINS
Michael Schirner, Lia Domide, Dionysios Perdikis, Paul Triebkorn,...., Agnes Flöel, ...Jochen Mersmann, Viktor Jirsa, Petra Ritter
NeuroImage. 251:118973 (2022)
Maturation- and aging-related differences in electrophysiological correlates of error detection and error awareness
Franka Thurm, Shu-Chen Li, Dorothea Hämmerer
Neuropsychologia. 143:107476 (2020)
Unimanual sensorimotor learning—A simultaneous EEG-fMRI aging study
Sabrina Chettouf, Paul Triebkorn, Andreas Daffertshofer, Petra Ritter
Hum Brain Mapp. 2022;43:2348–2364 (2022)
Are unimanual movements bilateral?
Sabrina Chettouf, Laura M. Rueda-Delgado, Ralph de Vries, Petra Ritter, Andreas Daffertshofer
Neurosci & Biobehav Rev. 113:39-50 (2020)
The importance of standards for sharing of computational models and data
Russell A. Poldrack, Franklin Feingold, Michael J. Frank, Padraig Gleeson, Gilles de Hollander, Quentin JM Huys, Bradley C. Love, Christopher J. Markiewicz, Rosalyn Moran, Petra Ritter, Timothy T. Rogers, Brandon M. Turner, Tal Yarkoni, Ming Zhan, Jonathan D. Cohen
Comput Brain & Behav. 2(3-4):229-232 (2019)
Bridging scales in Alzheimer’s disease: Biological framework for brain simulation with The Virtual Brain
Leon Stefanovski, Jil Mona Meier, Roopa Pai, Paul Triebkorn, Tristram Lett, Leon Martin, Konstantin Bülau, Martin Hofmann-Apitius, Ana Solodkin, Anthony McIntosh, Petra Ritter
Front Neuroinform. 15:630172 (2021)
Movement disorders after hypoxic brain injury following cardiac arrest in adults
F. Scheibe, W. J. Neumann, C. Lange, M. Scheel, C. Furth, M. Köhnlein, P. Mergenthaler, J. Schultze‐Amberger, P. Triebkorn, P. Ritter, A. A. Kühn, A. Meisel
Eur J Neurol. 27(10):1937-194 (2020)
Dynamic functional connectivity between order and randomness and its evolution across the human adult lifespan
Demian Battaglia, Thomas Boudou, Enrique C.A. Hansen, Diego Lombardo, Sabrina Chettouf, Andreas Daffertshofer, Anthony R. McIntosh, Joelle Zimmermann, Petra Ritter, Viktor Jirsa
NeuroImage. 222:117156 (2020)
Brain network simulations indicate effects of neuregulin-1 genotype on excitation-inhibition balance in cortical dynamics
Pedro Costa Klein, Ulrich Ettinger, Michael Schirner, Petra Ritter, Dan Rujescu, Peter Falkai, Nikolaos Koutsouleris, Lana Kambeitz-Ilankovic, Joseph Kambeitz
Cereb Cortex. 31(4):2013-2025 (2020)
The importance of cerebellar connectivity on simulated brain dynamics
Fulvia Palesi, Roberta Maria Lorenzi, Claudia Casellato, Petra Ritter, Viktor Jirsa, Claudia A.M. Gandini Wheeler-Kingshott and Egidio D’Angelo
Front Cell Neurosci. 14:240 (2020)
Identifying optimal working points of individual Virtual Brains: A large-scale brain network modelling study
Paul Triebkorn, Joelle Zimmermann, Leon Stefanovski, Dipanjan Roy, Ana Solodkin, Viktor Jirsa, Gustavo Deco, Michael Breakspear, Anthony Randal McIntosh, Petra Ritter
bioRxiv
Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences
Kathy Y Liu, Rogier A Kievit, Kamen A Tsvetanov, Matthew J Betts, Emrah Düzel, James B Rowe, Cam-CAN, Robert Howard and Dorothea Hämmerer
Nat Commun. 11(1):1712 (2020)
Linking molecular pathways and large-scale modeling to assess candidate disease mechanisms and pharmacodynamics in Alzheimer’s disease
Leon Stefanovski, Paul Triebkorn, Andreas Spiegler, Margarita-Arimatea Diaz-Cortes, Ana Solodkin, Viktor Jirsa, Anthony Randal McIntosh and Petra Ritter for the Alzheimer's Disease Neuroimaging Initiative
Front Comput Neurosci. 13:54 (2019)
A macaque connectome for large-scale network simulations in The Virtual Brain
Kelly Shen, Gleb Bezgin, Michael Schirner, Petra Ritter, Stefan Everling and Anthony R McIntosh
Sci Data. 6(1):123 (2019)
Modeling brain dynamics after tumor resection using The Virtual Brain
Hannelore Aerts, Michael Schirner, Thijs Dhollander, Ben Jeurissen, Eric Achten, Dirk Van Roost, Petra Ritter and Daniele Marinazzo
NeuroImage. 213: 116738 (2020)
European Ultrahigh-field Imaging Network for Neurodegenerative Diseases (EUFIND)
Emrah Düzel, Julio Acosta-Cabronero, David Berron, Geert Jan Biessels, Isabella Björkman-Burtscher, et al.
Alzheimer’s & Dementia. 11:538-549 (2019)
