Memories shape everyday behaviour, typically informing effective responses but sometimes driving maladaptive ones. This process engages complex patterns of neuronal activity across distributed brain networks, including the hippocampus. What features of neural activity underlie memory-guided behaviour? By considering spatio-temporally organised neuronal spiking and rhythmic fluctuations of the local field potentials, I will discuss in this talk recent findings that describe population-level patterns of activity supporting internal processing of mnemonic information. Notably, I will present cell type-selective and network pattern-informed interventions that allow drawing causal involvement of neural dynamics at the nexus of brain and behaviour, which can be used to prevent the expression of unwanted memories. Altogether, these data will highlight how fine-grained neural dynamics distributed across the hippocampus and partner circuits promote memory-guided behaviour, for better or worse.

About the Speaker: David Dupret’s Ph.D. in Neuroscience at the Institute François Magendie (INSERM, University of Bordeaux, France) was awarded with the French Neuroscience Association’s 2007 Ph.D. Year Prize. David has also held an ‘Agrégation ès’ Biological and Earth Sciences (Ministry of Education, France) since 2000. He joined the group of Prof Jozsef Csicsvari at the MRC Anatomical Neuropharmacology Unit in September 2007 as a Visiting fellow. In 2009, David was appointed as a MRC postdoctoral scientist, and in 2011, was promoted to tenured MRC Programme Leader in 2014. In 2016, David was named a Scholar of the FENS-Kavli Network of Excellence and, in 2018, received the Boehringer Ingelheim-FENS 2018 Research Award for his work on dynamics of neuronal assemblies in memory processes.In 2020, David was awarded the title of Professor of Neuroscience by the University of Oxford, and appointed a Tutorial Fellow in Biomedical Sciences at St Edmund Hall in conjunction with the Department of Physiology, Anatomy and Genetics. Source, www.dpag.ox.ac.uk/team/david-dupret

Source, www.dpag.ox.ac.uk/team/david-dupret

This invited talk is hosted by SFB1315 Assoc PI Silvia Viana da Silva.

Certificate of attendance: Please contact team assistant serenella.brinati.1(at)hu-berlin.de>

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