A combined perturbation and modelling approach to understand and modulate the interactions between brain oscillations underlying memory consolidation in human NREM sleep

We combine experimental work in human subjects with computational modelling of neurophysiological events, which correlate with and possibly underlie sleep-dependent memory consolidation in humans. Our main goals are to mechanistically understand the spatiotemporal patterns of slow oscillations, δ-waves, spindle, and sharp-wave ripple activity, to infer mechanisms of spatially distributed systems memory consolidation underlying the observed spatiotemporal patterns, to mechanistically understand and predict the impact of transcranial current stimulation on these oscillatory events, and to design efficient stimulation protocols for manipulating those patterns.

Image Time frequency representation (TFR) in the frequency range of 5 to 20 Hz for SO (left) and delta (right) events. Courtesy of B03 members

Archive – B03 (SFB1315/1)